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. 2018 Jun 5;22(1):147.
doi: 10.1186/s13054-018-2084-z.

Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores

Gunnar Elke  1 , Frank Bloos  2   3 , Darius Cameron Wilson  4 , Patrick Meybohm  5 ; SepNet Critical Care Trials Group
Affiliations

Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores

Gunnar Elke et al. Crit Care. .
No abstract available

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Conflict of interest statement

Ethics approval and consent to participate

The study protocol of the Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT) was approved by the ethics board of Jena University Hospital (Internal File No. 2242–03/08). Written informed consent was obtained from all patients or their legal representatives.

Consent for publication

No individual participant data are reported that would require consent to publish from the participant (or legal parent or guardian for children).

Competing interests

FB reported receiving lecture honoraria from biosyn, Gilead, and CSL Behring and public funding for the SISPCT trial to his department by the German Federal Ministry of Education and Research as well as unrestricted research grants for the SISPCT trial by biosyn and Thermo Fisher Scientific. DCW is an employee of B·R·A·H·M·S GmbH. All other authors declared that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Prediction of sepsis-related multiple organ failure in low (≤7 points) and moderate (8–13 points) SOFA severity patient populations. Cox regression and AUROC analysis for 28-day mortality due to sepsis-related multiple organ failure. Univariate Cox regression was compared for each biomarker and clinical score in the (a) low (≤7 points) and (b) moderate (8–13 points) SOFA severity subgroups. Multivariate Cox regression analysis was corrected for age and the presence of comorbidities. Abbreviations: APACHE II Acute Physiology and Chronic Health Evaluation II (score), AUROC area under the receiver operating characteristic curve, CI confidence interval, CRP C-reactive protein, HR hazard ratio, IQR interquartile range, LR likelihood ratio, MOF multiple organ failure, MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, SAPS II Simplified Acute Physiology Score II, SOFA Sepsis-related Organ Failure Assessment
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References

    1. Elke G, Bloos F, Wilson DC, et al. The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial. Crit Care. 2018;22:79. doi: 10.1186/s13054-018-2001-5. - DOI - PMC - PubMed
    1. Andaluz-Ojeda D, Nguyen HB, Meunier-Beillard N, et al. Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Ann Intensive Care. 2017;7:15. doi: 10.1186/s13613-017-0238-9. - DOI - PMC - PubMed
    1. Bernal-Morell E, García-Villalba E, Vera MDC, et al. Usefulness of midregional pro-adrenomedullin as a marker of organ damage and predictor of mortality in patients with sepsis. J Inf Secur. 2018;76:249–257. - PubMed
    1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287. - DOI - PMC - PubMed
    1. Ince C, Mayeux PR, Nguyen T, et al. The endothelium in Sepsis. Shock. 2016;45:259–270. doi: 10.1097/SHK.0000000000000473. - DOI - PMC - PubMed

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