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. 2018 Jun;109(6):1065-1071.e1.
doi: 10.1016/j.fertnstert.2018.01.039. Epub 2018 Jun 2.

Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

Brianna M Lyttle Schumacher  1 , Anne Marie Z Jukic  2 , Anne Z Steiner  3
Affiliations

Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

Brianna M Lyttle Schumacher et al. Fertil Steril. 2018 Jun.

Abstract

Objective: To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.

Design: Prospective cohort study.

Setting: Not applicable.

Patient(s): Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally.

Intervention(s): None.

Main outcome measure(s): Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks' gestation.

Result(s): After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ≤ 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ≥ 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3).

Conclusion(s): AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.

Keywords: Antimüllerian hormone; diminished ovarian reserve; miscarriage; pregnancy loss.

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Figures

Figure 1
Figure 1
Unadjusted Kaplan Meier curves for time to miscarriage by anti-mϋllerian hormone (AMH) level. (Log Rank test P=0.008)
See this image and copyright information in PMC

Comment in

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