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Comment
. 2018 Sep 1;24(17):4062-4065.
doi: 10.1158/1078-0432.CCR-18-1314. Epub 2018 Jun 5.

PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey

Panagiotis A Konstantinopoulos  1 , Ursula A Matulonis  2
Affiliations
Comment

PARP Inhibitors in Ovarian Cancer: A Trailblazing and Transformative Journey

Panagiotis A Konstantinopoulos et al. Clin Cancer Res. .

Abstract

PARP inhibitors have transformed treatment for ovarian cancer, a cancer notable for homologous recombination (HR) deficiencies and aberrant DNA repair, especially in the high-grade serous subtype. PARP inhibitors are now approved for recurrent ovarian cancer as maintenance following response to platinum chemotherapy and BRCA-mutated (BRCAm) cancer treatment. Clin Cancer Res; 24(17); 4062-5. ©2018 AACRSee related article by Ison et al., p. 4066.

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