Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 23:11:125-127.
doi: 10.2147/IMCRJ.S153099. eCollection 2018.

Anaphylactic reactions due to pantoprazole: case report of two cases

Pramendra Prasad Gupta  1 , Rabin Bhandari  1 , Deebya Raj Mishra  2 , Krishna Kumar Agrawal  3 , Rupak Bhandari  1 , Sunil Jirel  1 , Gyanendra Malla  1
Affiliations

Anaphylactic reactions due to pantoprazole: case report of two cases

Pramendra Prasad Gupta et al. Int Med Case Rep J. .

Abstract

Background: Drug-induced hypersensitivity reaction is of great clinical significance in therapeutics. The objective of this reporting of two cases is to show that anaphylaxis reaction can occur with pantoprazole.

Case summaries: A 38-year-old female reported to the emergency ward in a critical condition, with a history of periorbital edema, edema of the skin, pruritus, nausea, vomiting, and difficulty breathing 20 minutes after ingestion of a pantoprazole 40 mg tablet. A 32-year-old female reported to the emergency ward in a critical condition, with complaints of rashes all over the body, itching on the whole body, and swollen lips and eyes after ingestion of a pantoprazole 40 mg tablet.

Conclusion: It is necessary for all health care providers to know that pantoprazole can cause anaphylaxis, which is a life-threatening reaction, and to be cautious while prescribing it.

Keywords: anaphylactic reactions; pantoprazole; proton pump inhibitors.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

    1. Walker AI, Werfel S, Kick G, Przybilla B. Repeated anaphylactic responses induced by oral challenge with ranitidine. Acta Derm Venereol. 2010;90(2):189. - PubMed
    1. Sobrevia Elfau MT, Garcés Sotillos M, Ferrer Clavería L, Segura Arazuri N, Monzón Ballarin S, Colás Sanz C. Study of cross-reactivity between proton pump inhibitors. J Investig Allergol Clin Immunol. 2010;20(2):157–161. - PubMed
    1. Song WJ, Kim MH, Lee SM, et al. Two cases of H2-receptor antagonist hypersensitivity and cross-reactivity. Allergy Asthma Immunol Res. 2011;3(2):128–131. - PMC - PubMed
    1. Frampton JE, McTavish D. Ranitidine: a pharmcoeconomic evaluation of its use in acid related disorders. Pharmcoeconomics. 1994;6:57–89. - PubMed
    1. Hepner DL, Castells MC. Anaphylaxis during the perioperative period. Anesth Analg. 2003;97(5):1381–1395. - PubMed

LinkOut - more resources