Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jun 19;1(1):22.
doi: 10.1038/s41698-017-0022-1. eCollection 2017.

Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care

Ugljesa Djuric  1   2 , Gelareh Zadeh  1 , Kenneth Aldape  1   2   3 , Phedias Diamandis  1   2   3
Affiliations

Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care

Ugljesa Djuric et al. NPJ Precis Oncol. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Figures

Fig. 1
Fig. 1
Diagnostic decision-making algorithms in pathology. a Digital image of a H&E stained slide showing classic histologic features of an anaplastic oligodendroglioma, WHO grade III. b Unaided human-based classification algorithms utilize simple and highly reproducible decision tree-based approaches. Even with new more objective molecular tools, the need for highly uniform and reproducible diagnostic reporting limits the number of alterations that can be extracted from data-rich molecular data sets. c, d Machine learning-based approaches may allow for multi-parametric feature extraction and aggregation that permit even subtle but reproducible groups of features to be integrated into classification schemes. DNNs may thus tolerate reliable extraction of a larger number of unappreciated features that can be correlated with specific entities, outcomes, and molecular changes. IDH isocitrate dehydrogenase, IDH-mut IDH-mutated, IDH-wt IDH-wildtype, CIC capicua, Oligo oligodendroglioma, Astro astrocytoma, Oligoastro oligoastrocytoma, WHO World Health Organization malignancy grading scheme
See this image and copyright information in PMC

References

    1. Turk JL. Rudolf Virchow—father of cellular pathology. J. R. Soc. Med. 1993;86:688–689. - PMC - PubMed
    1. McLendon R, et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061–1068. doi: 10.1038/nature07385. - DOI - PMC - PubMed
    1. Cancer Genome Atlas Research Network et al. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N. Engl. J. Med. 2015;372:2481–2498. doi: 10.1056/NEJMoa1402121. - DOI - PMC - PubMed
    1. Ramaswamy V, Taylor MD. Fall of the optical wall: freedom from the tyranny of the microscope improves glioma risk stratification. Cancer Cell. 2016;29:137–138. doi: 10.1016/j.ccell.2016.01.009. - DOI - PubMed
    1. Sackett DL. The rational clinical examination. A primer on the precision and accuracy of the clinical examination. J. Am. Med. Assoc. 1992;267:2638–2644. doi: 10.1001/jama.1992.03480190080037. - DOI - PubMed