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Review
. 2018 Jun 7;11(2):58.
doi: 10.3390/ph11020058.

TRPM Family Channels in Cancer

Aline Hantute-Ghesquier  1 , Aurélien Haustrate  2   3 , Natalia Prevarskaya  4 , V'yacheslav Lehen'kyi  5   6
Affiliations
Review

TRPM Family Channels in Cancer

Aline Hantute-Ghesquier et al. Pharmaceuticals (Basel). .

Abstract

Members of the TRPM ("Melastatin") family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy.

Keywords: TRPM channels; cancer; target; therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
General structure of the TRPM family of channels.
Figure 2
Figure 2
Role of different TRPM channels in cancer. (+) for the increase of function, (−) for the decrease of function.
See this image and copyright information in PMC

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