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. 2017 Dec 29;20(2):67-74.
doi: 10.1515/bjmg-2017-0033. eCollection 2017 Dec.

Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients

Tuna A  1 , Ozturk G  1 , Gerceker Tb  1 , Karaca E M.D., Associacte Professor  2 , Onay H  2 , Guvenc Sm  2 , Cogulu O  2
Affiliations

Superoxide Dismutase 1 and 2 Gene Polymorphism in Turkish Vitiligo Patients

Tuna A et al. Balkan J Med Genet. .

Abstract

Vitiligo is an acquired disease of unknown etiology. Several theories have been proposed to understand the pathogenesis. The role of oxidative stress has been getting more important in recent years. One of the primary antioxidant enzymes in vitiligo is the superoxide dismutase (SOD). The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A/C and SOD2 A16V (C/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A/C and SOD2 A16V (C/T) polymorphism allele frequencies were compared by using χ2 tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C/T) polymorphism, a significant difference was determined for the distribution of the genotypes [p = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients.

Keywords: SOD1; SOD2; Superoxide dismutase (SOD); Vitiligo.

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Figures

Figure 1
Figure 1
Gel images of each genotype along with DNA ladder (100 bp plus).
Figure 2
Figure 2
The sequencing chromatogram of SOD1 35 A/C and SOD2 Ala9Val (C/T) polymorphisms. A) SOD1 35 AA wild type; B) SOD1 35 AC heterozygotes; C) SOD2 Ala9Val TT wild type; D) SOD2 Ala9Val TC heterozygotes; E) SOD2 Ala9Val CC homozygotes.
See this image and copyright information in PMC

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