Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Apr;7(2):160-170.
doi: 10.21037/tlcr.2018.03.26.

Image guidance in proton therapy for lung cancer

Miao Zhang  1 , Wei Zou  2 , Boon-Keng Kevin Teo  2
Affiliations
Review

Image guidance in proton therapy for lung cancer

Miao Zhang et al. Transl Lung Cancer Res. 2018 Apr.

Abstract

Proton therapy is a promising but challenging treatment modality for the management of lung cancer. The technical challenges are due to respiratory motion, low dose tolerance of adjacent normal tissue and tissue density heterogeneity. Different imaging modalities are applied at various steps of lung proton therapy to provide information on target definition, target motion, proton range, patient setup and treatment outcome assessment. Imaging data is used to guide treatment design, treatment delivery, and treatment adaptation to ensure the treatment goal is achieved. This review article will summarize and compare various imaging techniques that can be used in every step of lung proton therapy to address these challenges.

Keywords: Proton therapy; imaging guidance; lung cancer.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Similar articles

See all similar articles

Cited by

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30. 10.3322/caac.21332 - DOI - PubMed
    1. Ramroth J, Cutter D, Darby S, et al. Dose and fractionation in radiotherapy of curative intent for non-small-cell lung cancer: Meta-analysis of randomized trials. Int J Radiat Oncol Biol Phys 2016;96:736-47. 10.1016/j.ijrobp.2016.07.022 - DOI - PMC - PubMed
    1. Hedin E, Bäck A. Influence of different dose calculation algorithms on the estimate of NTCP for lung complications. J Appl Clin Med Phys 2013;14:127-39. 10.1120/jacmp.v14i5.4316 - DOI - PMC - PubMed
    1. Liao ZX, Komaki RR, Thames HD, et al. Influence of technologic advances on outcomes in patients with unresectable, locally advanced non–small-cell lung cancer receiving concomitant chemoradiotherapy. Int J Radiat Oncol Biol Phys 2010;76:775-81. 10.1016/j.ijrobp.2009.02.032 - DOI - PubMed
    1. Vedam SS, Keall PJ, Kini VR, et al. Acquiring a four-dimensional computed tomography dataset using an external respiratory signal. Phys Med Biol 2003;48:45-62. 10.1088/0031-9155/48/1/304 - DOI - PubMed

LinkOut - more resources