Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr 6;5(5):ofy074.
doi: 10.1093/ofid/ofy074. eCollection 2018 May.

Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States

Affiliations

Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States

Fiorella Krapp et al. Open Forum Infect Dis. .

Abstract

Reports of extensively drug-resistant and pan-drug-resistant Klebsiella pneumoniae (XDR-KP and PDR-KP) cases are increasing worldwide. Here, we report a case of XDR-KP with an in-depth molecular characterization of resistance genes using whole-genome sequencing, and we review all cases of XDR-KP and PDR-KP reported in the United States to date.

Keywords: Klebsiella pneumoniae; antibiotic resistance; extensively drug-resistant; resistance genes.

PubMed Disclaimer

References

    1. Bathoorn E, Tsioutis C, da Silva Voorham JM et al. . Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call. J Antimicrob Chemother 2016; 71:1207–12. - PubMed
    1. Bi W, Liu H, Dunstan RA et al. . Extensively drug-resistant Klebsiella pneumoniae causing nosocomial bloodstream infections in China: molecular investigation of antibiotic resistance determinants, informing therapy, and clinical outcomes. Front Microbiol 2017; 8:1230. - PMC - PubMed
    1. Sonnevend A, Ghazawi A, Hashmey R et al. . Multihospital occurrence of pan-resistant Klebsiella pneumoniae sequence type 147 with an ISEcp1-directed blaOXA-181 insertion in the mgrB gene in the United Arab Emirates. Antimicrob Agents Chemother. 2017; 61(7). - PMC - PubMed
    1. Chen L, Todd R, Kiehlbauch J et al. . Notes from the field: pan-resistant New Delhi metallo-beta-lactamase-producing Klebsiella pneumoniae—Washoe County, Nevada, 2016. MMWR Morb Mortal Wkly Rep 2017; 66:33. - PMC - PubMed
    1. Tamma PD, Huang Y, Opene BN, Simner PJ. Determining the optimal carbapenem MIC that distinguishes carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother 2016; 60:6425–9. - PMC - PubMed

LinkOut - more resources