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Review
. 2018 Mar 8:18:58-64.
doi: 10.1016/j.ijcha.2018.03.001. eCollection 2018 Mar.

High risk electrocardiographic markers in Brugada syndrome

Dimitrios Asvestas  1 , Gary Tse  2   3 , Adrian Baranchuk  4 , George Bazoukis  1 , Tong Liu  5 , Athanasios Saplaouras  1 , Panagiotis Korantzopoulos  6 , Christina Goga  1 , Michael Efremidis  1 , Antonios Sideris  1 , Konstantinos P Letsas  1
Affiliations
Review

High risk electrocardiographic markers in Brugada syndrome

Dimitrios Asvestas et al. Int J Cardiol Heart Vasc. .

Abstract

Several clinical, electrocardiographic (ECG) and electrophysiological markers have been proposed to provide optimal risk stratification in patients with Brugada syndrome (BrS). Of the different markers, only a spontaneous type 1 ECG pattern has clearly shown a sufficiently high predictive value. This review article highlights specific ECG markers based on depolarization and/or repolarization that have been associated with an increased risk of arrhythmic events in patients with BrS.

Keywords: Brugada syndrome; Electrocardiogram; Sudden cardiac death.

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Figures

Fig. 1
Fig. 1
Spontaneous type 1 ECG pattern of BrS in lead V1.
Fig. 2
Fig. 2
Beta angle helps distinguish type 2 Brugada pattern from Brugada phenocopies.
Fig. 3
Fig. 3
Base of triangle helps distinguish type 2 Brugada pattern from Brugada phenocopies.
Fig. 4
Fig. 4
Fragmented QRS complex.
Fig. 5
Fig. 5
Baseline (top) and after drug challenge (bottom) electrocardiographic tracings showing spontaneous epsilon-like waves (arrows) in subjects with Brugada phenotype.
Fig. 6
Fig. 6
Inferolateral early repolarization pattern.
See this image and copyright information in PMC

References

    1. Antzelevitch C., Yan G.X., Ackerman M.J., Borggrefe M., Corrado D., Guo J. J-wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge. Heart Rhythm. 2016;13:e295–324. - PMC - PubMed
    1. Antzelevitch C., Patocskai B. Brugada syndrome: clinical, genetic, molecular, cellular, and ionic aspects. Curr. Probl. Cardiol. 2016;41:7–57. - PMC - PubMed
    1. Antzelevitch C., Brugada P., Borggrefe M., Brugada J., Brugada R., Corrado D. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005;111:659–670. - PubMed
    1. Tse G., Liu T., Li K.H., Laxton V., Chan Y.W., Keung W. Electrophysiological mechanisms of Brugada syndrome: insights from pre-clinical and clinical studies. Front. Physiol. 2016;7:467. - PMC - PubMed
    1. Wilde A.A., Postema P.G., Di Diego J.M., Viskin S., Morita H., Fish J.M. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. J. Mol. Cell. Cardiol. 2010;49:543–553. - PMC - PubMed

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