Evaluation of ultrasensitive CRP and microalbuminuria as cardiovascular risk markers in type 2 diabetic moroccan patients

Abstract

Introduction: Type 2 diabetes is a chronic disease whose prevalence is increasing exponentially. This condition is a risk factor for cardiovascular disease, the leading cause of death among diabetics.

Aim: To study the correlation between hs CRP, microalbuminuria, diabetes monitoring parameters and the presence of vascular complications in a group of non-insulin dependent diabetic patients followed in endocrinology department of the Moulay Ismail Military Hospital in Meknes.

Methods: The study involved 250 patients with type 2 diabetes and 120 control subjects. Patients were subduvised on 2 groups: group I consisting of patients without diabetes vascular complications. Group II involved patients with at least one vascular complication. The parameters measured were age, sex, BMI, duration of diabetes and the presence of vascular complications. The studied biological parameters were hs CRP, microalbuminuria, HbA1c and lipid profile.

Results: Diabetic patients with complications had significantly higher levels of hs CRP and microalbuminuria compared with diabetic patients without complications and with controls (8.37 vs 5.94 vs 2.63; p <0.001 vs 62.10 34 56 vs 5.67; p <0.0001). The rate of hs CRP were significantly correlated with HA1c, total cholesterol, the LDL-C, index atherogenicity microalbuminuria and duration of diabetes for the two patient groups. A significant correlation between hs CRP and age was only found in Group I.

Conclusion: CRP appears to be interested in the detection of vascular complications in diabetic type2.