Premise for Standardized Sepsis Models
- PMID: 29877959
- PMCID: PMC6281773
- DOI: 10.1097/SHK.0000000000001164
Premise for Standardized Sepsis Models
Abstract
Sepsis morbidity and mortality exacts a toll on patients and contributes significantly to healthcare costs. Preclinical models of sepsis have been used to study disease pathogenesis and test new therapies, but divergent outcomes have been observed with the same treatment even when using the same sepsis model. Other disorders such as diabetes, cancer, malaria, obesity, and cardiovascular diseases have used standardized, preclinical models that allow laboratories to compare results. Standardized models accelerate the pace of research and such models have been used to test new therapies or changes in treatment guidelines. The National Institutes of Health mandated that investigators increase data reproducibility and the rigor of scientific experiments and has also issued research funding announcements about the development and refinement of standardized models. Our premise is that refinement and standardization of preclinical sepsis models may accelerate the development and testing of potential therapeutics for human sepsis, as has been the case with preclinical models for other disorders. As a first step toward creating standardized models, we suggest standardizing the technical standards of the widely used cecal ligation and puncture model and creating a list of appropriate organ injury and immune dysfunction parameters. Standardized sepsis models could enhance reproducibility and allow comparison of results between laboratories and may accelerate our understanding of the pathogenesis of sepsis.
References
-
- Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care T Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med. 2016;193(3):259–72. - PubMed
Publication types
MeSH terms
Grants and funding
- R35 GM118097/GM/NIGMS NIH HHS/United States
- R01 GM113228/GM/NIGMS NIH HHS/United States
- R01 GM072808/GM/NIGMS NIH HHS/United States
- R01 GM121102/GM/NIGMS NIH HHS/United States
- R01 GM104323/GM/NIGMS NIH HHS/United States
- T32 GM095442/GM/NIGMS NIH HHS/United States
- R21 AI112887/AI/NIAID NIH HHS/United States
- R01 GM117519/GM/NIGMS NIH HHS/United States
- P50 GM111152/GM/NIGMS NIH HHS/United States
- R01 GM040586/GM/NIGMS NIH HHS/United States
- T32 GM008440/GM/NIGMS NIH HHS/United States
- T32 GM086308/GM/NIGMS NIH HHS/United States
- R01 GM109779/GM/NIGMS NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials