Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Aug;40(4):377-387.
doi: 10.1111/ics.12470. Epub 2018 Aug 15.

Vichy Thermal Spring Water (VTSW), a cosmetic ingredient of potential interest in the frame of skin ageing exposome: an in vitro study

C Tacheau  1 , F Weisgerber  1 , D Fagot  1 , P Bastien  1 , M P Verdier  1 , M Liboutet  2 , G Sore  2 , B A Bernard  3
Affiliations

Vichy Thermal Spring Water (VTSW), a cosmetic ingredient of potential interest in the frame of skin ageing exposome: an in vitro study

C Tacheau et al. Int J Cosmet Sci. 2018 Aug.

Abstract

Objective: To study the effects of the very high minerality Vichy Thermal Spring Water (VTSW) on human keratinocytes grown in vitro.

Methods: The effect of VTSW was monitored by full genome transcriptomic technology and immunofluorescence microscopy.

Results: In the presence of 50% VTSW, the expression of a number of skin homoeostasis-related genes is increased, specifically with respect to dermal-epidermal junction, epidermal cohesion and communication, keratinocyte proliferation-differentiation balance, antioxidant mechanisms and DNA repair.

Conclusion: This work suggests that VTSW could be considered as an ingredient of potential interest to address some of the deleterious effects of skin ageing exposome.

Keywords: Thermal Spring Water; exposome; keratinocyte; oxidative stress; skin ageing; transcriptomics.

PubMed Disclaimer

LinkOut - more resources