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. 1985 Jun;82(11):3790-3.
doi: 10.1073/pnas.82.11.3790.

The alpha-spectrin gene is on chromosome 1 in mouse and man

K Huebner, A P Palumbo, M Isobe, C A Kozak, S Monaco, G Rovera, C M Croce, P J Curtis

The alpha-spectrin gene is on chromosome 1 in mouse and man

K Huebner et al. Proc Natl Acad Sci U S A. 1985 Jun.

Abstract

By using alpha-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for alpha-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human alpha-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies.

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