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Review
. 2018 Jun 7;24(21):2236-2246.
doi: 10.3748/wjg.v24.i21.2236.

Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells

Ting-Ting Li  1 , Hao Liu  1 , Jiang Yu  1 , Guang-Yao Shi  2 , Li-Ying Zhao  1 , Guo-Xin Li  3
Affiliations
Review

Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells

Ting-Ting Li et al. World J Gastroenterol. .

Abstract

Gastric cancer (GC), with its high incidence and mortality rates, is a highly fatal cancer that is common in East Asia particularly in China. Its recurrence and metastasis are the main causes of its poor prognosis. Circulating tumor cells (CTCs) or other blood biomarkers that are released into the circulating blood stream by tumors are thought to play a crucial role in the recurrence and metastasis of gastric cancer. Therefore, the detection of CTCs and other blood biomarkers has an important clinical significance; in fact, they can help predict the prognosis, assess the staging, monitor the therapeutic effects and determine the drug susceptibility. Recent research has identified many blood biomarkers in GC, such as various serum proteins, autoantibodies against tumor associated antigens, and cell-free DNAs. The analysis of CTCs and circulating cell-free tumor DNA (ctDNA) in the peripheral blood of patients with gastric cancer is called as liquid biopsy. These blood biomarkers provide the disease status for individuals and have clinical meaning. In this review, we focus on the recent scientific advances regarding CTCs and other blood biomarkers, and discuss their origins and clinical meaning.

Keywords: Autoantibodies; Biomarker; Cell-free DNA; Circulating tumor cells; Gastric cancer.

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Conflict of interest statement

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Figures

Figure 1
Figure 1
Flow chart of current and potential applications of circulating tumor cell. Circulating tumor cells (CTCs): The blood samples from cancer patients are processed through various isolation/enrichment and detection techniques. CTCs are usually captured along with contaminating leukocytes. Various detection methods are utilized to detect the rare cell population in the bloodstream.
See this image and copyright information in PMC

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