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Review
. 2018 Apr 25:12:1178223418767666.
doi: 10.1177/1178223418767666. eCollection 2018.

Roles of Extracellular Vesicles in Metastatic Breast Cancer

Junya Peng  1 , Wenqian Wang  2 , Surong Hua  3 , Lulu Liu  1
Affiliations
Review

Roles of Extracellular Vesicles in Metastatic Breast Cancer

Junya Peng et al. Breast Cancer (Auckl). .

Abstract

Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. This review also covers EV roles as biomarker and therapeutic target in clinical application.

Keywords: Extracellular vesicles; breast cancer.

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Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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