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. 2018 May 24:9:357.
doi: 10.3389/fneur.2018.00357. eCollection 2018.

Non-Motor Symptoms as Predictors of Quality of Life in Egyptian Patients With Parkinson's Disease: A Cross-Sectional Study Using a Culturally Adapted 39-Item Parkinson's Disease Questionnaire

Ali S Shalash  1 , Eman Hamid  1 , Hanan Hani Elrassas  2 , Ahmed Safwat Bedair  1 , Abdelrahman Ibrahim Abushouk  3 , Mohamed Khamis  1 , Mostafa Hashim  2 , Nahed Salah-Eldin Ahmed  1 , Samia Ashour  1 , Mahmoud Elbalkimy  1
Affiliations

Non-Motor Symptoms as Predictors of Quality of Life in Egyptian Patients With Parkinson's Disease: A Cross-Sectional Study Using a Culturally Adapted 39-Item Parkinson's Disease Questionnaire

Ali S Shalash et al. Front Neurol. .

Abstract

Objective: The prevalence of non-motor symptoms (NMSs) and their impact on health-related quality of life (HRQoL) in Parkinson's disease (PD) has been reported inconsistently among different populations. In this study, we aimed to investigate the NMSs and HRQoL profiles and their correlation in Egyptian PD patients, using a culturally adapted Arabic version of the 39-item Parkinson's disease questionnaire (PDQ-39).

Methods: Ninety-seven PD patients were rated using the unified Parkinson's disease rating scale (UPDRS), the non-motor symptoms scales (NMSS), Beck depression inventory (BDI), and the Arabic version of PDQ-39. We used the Spearman's rank correlation and multiple linear regression analyses to evaluate the relationship between NMSs domains and HRQoL dimensions.

Results: Fatigue/sleep (91.3%) and mood/cognitive disturbances (87%) were the most frequently and severely affected NMSS domains. Other common NMSs included urinary (75.9%), memory/attention (72.4%), gastrointestinal (67.8%), and cardiovascular problems (64.8%). The total NMSS scores were positively correlated with UPDRS I, II, and III scores. Depression was prevalent in 76.7% of PD patients. Moreover, all enrolled PD patients reported impairment in different HRQoL dimensions, especially mobility (98.9%), activities of daily living (97.8%), and emotional well-being (95.5%). The summary index of PDQ-39 was correlated to the total NMSS, UPDRS-I, UPDRS-II Off, UPDRS-III (Off and On states), and BDI scores.

Conclusion: This study showed the high prevalence of NMSs and the value of NMSS and BDI scores as predictors of HRQoL in Egyptian PD patients. Therefore, characterizing the NMSs profile is essential for tailoring management strategies for PD patients.

Keywords: 39-item Parkinson’s disease questionnaire; Arabic; Egypt; Parkinson’s disease; non-motor; quality of life.

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Figures

Figure 1
Figure 1
The frequency and severity of individual non-motor symptoms in the enrolled Parkinson’s disease patients.
See this image and copyright information in PMC

References

    1. Hirsch L, Jette N, Frolkis A, Steeves T, Pringsheim T. The incidence of Parkinson’s disease: a systematic review and meta-analysis. Neuroepidemiology (2016) 46:292–300.10.1159/000445751 - DOI - PubMed
    1. Martinez-Martin P. What is quality of life and how do we measure it? Relevance to Parkinson’s disease and movement disorders. Mov Disord (2017) 32:382–92.10.1002/mds.26885 - DOI - PubMed
    1. Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR. The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Mov Disord (2011) 26:399–406.10.1002/mds.23462 - DOI - PubMed
    1. Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord (2009) 24:1641–9.10.1002/mds.22643 - DOI - PubMed
    1. Dotchin CL, Jusabani A, Walker RW. Non-motor symptoms in a prevalent population with Parkinson’s disease in Tanzania. Parkinsonism Relat Disord (2009) 15:457–60.10.1016/j.parkreldis.2008.11.013 - DOI - PubMed

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