Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 21:28:245.
doi: 10.11604/pamj.2017.28.245.13518. eCollection 2017.

Early results for active infective endocarditis

Affiliations

Early results for active infective endocarditis

Mahdi Aithoussa et al. Pan Afr Med J. .

Abstract

Introduction: Cardiac surgery is frequently needed during active phase of infective endocarditis (IE). The purpose of this study was to analyze the immediate and late results and determine the risk factors for death.

Methods: We retrospectively reviewed 101 patients with IE operated in the active phase. The mean age was 40.5 ± 12.5 years. 16 patients (15.8%) were diagnosed with prosthetic valve endocarditis (PVE). 81 (80.9%) were in NYHA functional class III-IV. Blood cultures were positive in only 24 cases (23.9%).

Results: in-hospital mortality rate was 17.9% (18 cases). Multivariate analysis indentified five determinant predictor factors: congestive heart failure (CHF), renal insufficiency, high Euroscore, prolonged cardiopulmonary bypass time (> 120 min) and long ICU stay. The median follow-up period was 4.2 (2-6.5) years. Overall survival rate for all patients who survived surgery was 97% at 5 years and 91% at 10 years.

Conclusion: Despite high in-hospital mortality rate, when patients receive operation early in the active phase of their illness, late outcome may be good.

Keywords: Infective endocarditis; active phase; valvular surgery.

PubMed Disclaimer

Similar articles

References

    1. Vuyisile Nkomo T. Epidemiology and prevention of valvular heart disease and infective endocarditis in Africa. Heart. 2007 Dec;93(12):1510–9. - PMC - PubMed
    1. Carapetis JR. Rheumatic heart disease in Asia. Circulation. 2008;118(25):2748–53. - PubMed
    1. Habib G, Hoen B, Tornos P. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC): Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30(19):2369–41. - PubMed
    1. Thuny F, Grisoli D, Collart F, Habib G, Raoult D. Management of infective endocarditis: challenges and perspectives. Lancet. 2012;379(9819):965–75. - PubMed
    1. Fragomeni LSM, Vieira FF, Bajerski JCM, Falleiro RP, Hoppen G, Sartori I. Infective endocarditis Surgical Therapy. Arq Bras Cardiol. 2003;80(4):431–7. - PubMed