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Review
. 2018 May 31;7(6):e1018.
doi: 10.1002/cti2.1018. eCollection 2018.

Genome-wide association studies of multiple sclerosis

Chris Cotsapas  1   2 , Mitja Mitrovic  1   2
Affiliations
Review

Genome-wide association studies of multiple sclerosis

Chris Cotsapas et al. Clin Transl Immunology. .

Erratum in

Abstract

Large-scale genetic studies of multiple sclerosis have identified over 230 risk effects across the human genome, making it a prototypical common disease with complex genetic architecture. Here, after a brief historical background on the discovery and definition of the disease, we summarise the last fifteen years of genetic discoveries and map out the challenges that remain to translate these findings into an aetiological framework and actionable clinical understanding.

Keywords: disease risk genetics; genome‐wide association studies; immune‐mediated disease; multiple sclerosis.

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References

    1. Murray TJ. The history of multiple sclerosis: the changing frame of the disease over the centuries. J Neurol Sci 2009; 277(suppl 1): S3–S8. - PubMed
    1. Lassmann H, Wekerle H. The pathology of multiple sclerosis In: Compston A, ed. McAlpine's Multiple Sclerosis. Philadelphia, PA: Elsevier, 2006: 557–599.
    1. Rivers TM, Schwentker FF. Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 1935; 61: 689–702. - PMC - PubMed
    1. Kabat EA, Moore DH, Landow H. An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J Clin Invest 1942; 21: 571–577. - PMC - PubMed
    1. Ebers GC, Koopman WJ, Hader W et al The natural history of multiple sclerosis: a geographically based study: 8: familial multiple sclerosis. Brain 2000; 123(Pt 3): 641–649. - PubMed