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. 2018 Oct;48(10):3629-3636.
doi: 10.1007/s10803-018-3618-6.

Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum

S LaBianca  1   2 , A K Pagsberg  3 , K D Jakobsen  4   5 , A B Demur  6   7 , M Bartalan  6   7 , J LaBianca  5   8 , T Werge  6   7
Affiliations

Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum

S LaBianca et al. J Autism Dev Disord. 2018 Oct.

Abstract

Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum. 39 families with multiple individuals affected by ASD/ADHD were recruited from a psychiatric clinic. Diagnoses, functional and demographic characteristics were retrieved from journals while hospital admissions were identified in the Danish health register. An estimated fraction of 31% ASD/ADHD patients had never been hospitalized and 35% remained undiagnosed despite hospitalization. Cluster analysis identified trajectories that discriminate age of diagnosis, educational attainment to degree of severity, need of hospitalization and genetic risk.

Keywords: ADHD; ASD; Clusters of life trajectories; Co-morbidity; Genetic risk; National Health Register.

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