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Review
. 2018 Jun 6;19(6):1683.
doi: 10.3390/ijms19061683.

Proposed Molecular and miRNA Classification of Gastric Cancer

Lara Alessandrini  1 , Melissa Manchi  2 , Valli De Re  3 , Riccardo Dolcetti  4 , Vincenzo Canzonieri  5
Affiliations
Review

Proposed Molecular and miRNA Classification of Gastric Cancer

Lara Alessandrini et al. Int J Mol Sci. .

Abstract

Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause of cancer-related deaths. Despite some advances in therapies, long-term survival of patients with advanced disease remains poor. Different types of classification have been used to stratify patients with GC for shaping prognosis and treatment planning. Based on new knowledge of molecular pathways associated with different aspect of GC, new pathogenetic classifications for GC have been and continue to be proposed. These novel classifications create a new paradigm in the definition of cancer biology and allow the identification of relevant GC genomic subsets by using different techniques such as genomic screenings, functional studies and molecular or epigenetic characterization. An improved prognostic classification for GC is essential for the development of a proper therapy for a proper patient population. The aim of this review is to discuss the state-of-the-art on combining histological and molecular classifications of GC to give an overview of the emerging therapeutic possibilities connected to the latest discoveries regarding GC.

Keywords: EBV infection; gastric cancer; gene expression profile; gene mutation; miRNA; microsatellite; molecular gastric cancer subtype; preclinical models.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
The most relevant clinic-pathological and molecular features of TCGA subtypes.
Figure 2
Figure 2
The most relevant targetable pathways in GC.
See this image and copyright information in PMC

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