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Review
. 2018 May 23;4(2):62.
doi: 10.3390/jof4020062.

Sporotrichosis: From KOH to Molecular Biology

Roberto Arenas  1 , Carlos D Sánchez-Cardenas  2 , Lourdes Ramirez-Hobak  3 , Leon Felipe Ruíz Arriaga  4 , Ma Elisa Vega Memije  5
Affiliations
Review

Sporotrichosis: From KOH to Molecular Biology

Roberto Arenas et al. J Fungi (Basel). .

Abstract

Sporotrichosis is a cosmopolitan, chronic granulomatous mycosis, acquired by traumatic inoculation and caused by Sporothrix schenckii complex. Several methods of diagnostic are available, from KOH to molecular biology. In this review, we describe from the simplest (clinical diagnosis) to the most advanced diagnostic techniques (molecular biology).

Keywords: KOH; Sporothrix schenckii complex; histopathology; molecular biology; sporotrichosis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Skin biopsy stained with PAS in which yeast can be observed (40×).
Figure 2
Figure 2
Grocott stain in which the cigar-shaped yeasts are observed (40×).
Figure 3
Figure 3
Sporotrichosis, an asteroid body surrounded by numerous neutrophils is observed (PAS, 40×).
Figure 4
Figure 4
Skin Indirect immunofluorescence with sporotrichosis, fluorescent yeasts are observed (40×).
Figure 5
Figure 5
Phylogenetic tree of Sporothrix schenckii.
See this image and copyright information in PMC

References

    1. Arenas R. Micología Medica Ilustrada. 5th ed. McGraw-Hill; Mexico City, Mexico: 2014. pp. 160–172.
    1. Negrini T.D., Ferreira L.S., Alegranci P., Arthur R.A., Sundfeld P.P., Maia D.C., Spolidorio L.C. Carlos IZ Role of TLR-2 and fungal surface antigens on innate immune response against Sporothrix schenckii. Immunol. Investig. 2013;42:36–48. doi: 10.3109/08820139.2012.719982. - DOI - PubMed
    1. De Lima Barros M.B., de Almeida Paes R., Schubach A.O. Sporothrix schenckii and Sporotrichosis. Clin. Microbiol. Rev. 2011;24:633–654. doi: 10.1128/CMR.00007-11. - DOI - PMC - PubMed
    1. Lacaz C., Porto E., Martins J., Heins-Vaccari E., Takashi de Melo N. Tratado de Micologia Médica. 9th ed. Sarvier; Sao Paulo, Brazil: 2002. pp. 147–158.
    1. Gezuele E., Da Rosa D. Importance of the sporotrichosis asteroid body for the rapid diagnosis of sporotrichosis. Rev. Iberoam. Micol. 2005;22:147–150. doi: 10.1016/S1130-1406(05)70028-0. - DOI - PubMed

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