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. 2018 Oct 3;56(5):427-435.
doi: 10.2486/indhealth.2018-0014. Epub 2018 Jun 9.

Ventilatory disorders associated with occupational inhalation exposure to nitrogen trihydride (ammonia)

Masoud Neghab  1 , Ahmad Mirzaei  2 , Fatemeh Kargar Shouroki  2 , Mehdi Jahangiri  1 , Maryam Zare  3 , Saeed Yousefinejad  1
Affiliations

Ventilatory disorders associated with occupational inhalation exposure to nitrogen trihydride (ammonia)

Masoud Neghab et al. Ind Health. .

Abstract

Respiratory effects of long term exposure to low levels of ammonia have not been thoroughly investigated. In this cross sectional study, 124 male subjects (67 high exposed and 57 low exposed), occupationally exposed to low levels of ammonia and 120 male referent individuals were investigated. Airborne concentrations of ammonia were measured and subjects underwent spirometry tests prior to and at end of their daily work shift. Average concentrations of ammonia in the breathing zones of the high and low exposed employees were found to be 1.35 ± 4.59 and 0.29 ± 0.31 ppm, respectively. Additionally, mean baseline values of some parameters of pulmonary function such as Vital Capacity (VC) and Forced Expiratory Volume in the first second (FEV1) in the high exposed group were significantly lower than those of referent individuals. Similarly, significant reversible cross shift decrements were noted in FEV1, VC and Forced Vital Capacity (FVC) of exposed employees. These findings indicate that exposure to low levels of ammonia is associated with significant chronic irreversible and acute reversible decrements in the lungs' functional capacity.

Keywords: Ammonia; Lungs’ functional capacity; Occupational exposure; Petrochemical plant.

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References

    1. van Thriel C, Schäper M, Kiesswetter E, Kleinbeck S, Juran S, Blaszkewicz M, Fricke HH, Altmann L, Berresheim H, Brüning T. (2006) From chemosensory thresholds to whole body exposures-experimental approaches evaluating chemosensory effects of chemicals. Int Arch Occup Environ Health 79, 308–21. - PubMed
    1. Smeets MA, Bulsing PJ, van Rooden S, Steinmann R, de Ru JA, Ogink NW, van Thriel C, Dalton PH. (2007) Odor and irritation thresholds for ammonia: a comparison between static and dynamic olfactometry. Chem Senses 32, 11–20. - PubMed
    1. Rozman KK, Klaassen CD .(2007) Casarett and Doull’s toxicology: the basic science of poisons, 8th Ed., 718, McGraw-Hill, New York.
    1. U.S. Geological Survey (2009) Mineral commodity summaries, 114, U.S. Government Printing Office, Washington.
    1. Roney N, Llados F, Little S, Knaebel DB .(2004) Toxicological profile for ammonia, Agency for Toxic Substances and Disease Registry (ATSDR), 1–165, U.S. Department of Health and Human Services, Atlanta.

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