Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun;9(2):126-132.
doi: 10.1007/s13193-017-0618-5. Epub 2017 Feb 2.

Correlation of Pattern of Spread and Outcomes in Advanced Epithelial Ovarian Cancers

Amrutha Ramachandran  1 , Anupama Rajanbabu  1 , Kiran Gulabrao Bagul  1 , Keechilat Pavithran  2 , Dehannathparambil K Vijaykumar  1
Affiliations

Correlation of Pattern of Spread and Outcomes in Advanced Epithelial Ovarian Cancers

Amrutha Ramachandran et al. Indian J Surg Oncol. 2018 Jun.

Abstract

The purpose of this study was to correlate the pattern of spread with oncological outcomes in advanced ovarian cancer patients. This is a retrospective analysis of 55 consecutive patients who had advanced epithelial ovarian cancer or primary peritoneal carcinomatosis (stages 3C and 4) with primary surgical intervention as the initial modality of treatment. Based on the spread of disease, they were further classified into class A: disease confined to the pelvis (excluded); class B: disease extending to the lower abdomen and omentum; class C: diffuse small-bowel disease with or without A, B, or D; and class D: disease in the upper abdomen. There were 17 patients (30.9%) in class B, 17 (30.9%) in class C, and 21 (38.2%) in class D. The number of patients with suboptimal cytoreduction was highest in class C (six patients). At the end of follow-up (median 38.6 months), 16 patients had no evidence of disease and 26 patients were alive with disease. The 3-year overall survival rates in classes B, C, and D were 94.1, 52.5, and 93.3%, respectively. The 3-year progression-free survival rates were 55.8, 11.8, and 41.9%, respectively. The rates were lowest for class C. The differences in the overall survival rate (p < 0.001) and progression-free survival rate (p = 0.001) were statistically significant. In advanced ovarian cancer patients, the presence of disease in the small-bowel serosa and mesentery results in poorer outcomes in terms of overall and progression-free survival. The number of patients with suboptimal cytoreduction was also highest in this group.

Keywords: Advanced ovarian cancer; Epithelial ovarian cancers; Optimal cytoreduction; Pattern of spread; Survival.

PubMed Disclaimer

Conflict of interest statement

Compliance with Ethical StandardsNone

Figures

Fig. 1
Fig. 1
Flow diagram of the study cohort. Class B- Disease extending to the lower abdomen and omentum, Class C- Diffuse small bowel disease with or without a,b,d, Class D- Disease in the upper abdomen
Fig. 2
Fig. 2
Kaplan–Meier curve showing overall survival difference between the classes. b- Disease extending to the lower abdomen and omentum, c- Diffuse small bowel disease with or without a,b,d, d- Disease in the upper abdomen
Fig. 3
Fig. 3
Kaplan–Meier curve showing progression-free survival difference between the classes. b- Disease extending to the lower abdomen and omentum, c- Diffuse small bowel disease with or without a,b,d, d- Disease in the upper abdomen
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;1(5):136. - PubMed
    1. Heintz AP, Odicino F, Maisonneuve P, Quinn MA, Benedet JL, Creasman WT, Ngan HY, Pecorelli S, Beller U. Carcinoma of the ovary. FIGO 26th annual report on the results of treatment in gynecological cancer. Int J Gynaecol Obstet. 2006;95(Suppl 1):S161–S192. doi: 10.1016/S0020-7292(06)60033-7. - DOI - PubMed
    1. Elattar A, Bryant A, Winter-Roach BA, Hatem M, Naik R 2011.Optimal primary surgical treatment for advanced epithelial ovarian cancer. Cochrane Database Syst Rev. 10;(8) - PMC - PubMed
    1. Chi DS, Eisenhauer EL, Lang J, Huh J, Haddad L, Abu-Rustum NR, Sonoda Y, Levine DA, Hensley M, Barakat RR. What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)? Gynecol Oncol. 2006;103(2):559–564. doi: 10.1016/j.ygyno.2006.03.051. - DOI - PubMed
    1. Eisenkop SM, Spirtos NM, Lin WC. Optimal cytoreduction for advanced epithelial ovarian cancer: a commentary. Gynecol Oncol. 2006;103(1):329–335. doi: 10.1016/j.ygyno.2006.07.004. - DOI - PubMed

LinkOut - more resources