Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 25:9:258.
doi: 10.3389/fendo.2018.00258. eCollection 2018.

Aging Hallmarks: The Benefits of Physical Exercise

Alexandre Rebelo-Marques  1   2   3 , Adriana De Sousa Lages  1   4 , Renato Andrade  2   3   5 , Carlos Fontes Ribeiro  1 , Anabela Mota-Pinto  1 , Francisco Carrilho  4 , João Espregueira-Mendes  2   3   6   7   8
Affiliations
Review

Aging Hallmarks: The Benefits of Physical Exercise

Alexandre Rebelo-Marques et al. Front Endocrinol (Lausanne). .

Abstract

World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective strategies is encouraged.

Keywords: aging; cellular; hallmarks; life span; molecular; physical exercise.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Nine cellular hallmarks contributing to aging.
See this image and copyright information in PMC

References

    1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell (2013) 153(6):1194–217.10.1016/j.cell.2013.05.039 - DOI - PMC - PubMed
    1. Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol (2013) 75:621–44.10.1146/annurev-physiol-030212-183712 - DOI - PubMed
    1. Kaliman P, Párrizas M, Lalanza JF, Camins A, Escorihuela RM, Pallàs M. Neurophysiological and epigenetic effects of physical exercise on the aging process. Ageing Res Rev (2011) 10(4):475–86.10.1016/j.arr.2011.05.002 - DOI - PubMed
    1. Kirkwood TB. Understanding the odd science of aging. Cell (2005) 120(4):437–47.10.1016/j.cell.2005.01.027 - DOI - PubMed
    1. Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature (2008) 454(7208):1065.10.1038/nature07216 - DOI - PMC - PubMed

LinkOut - more resources