Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 20:2018:8681792.
doi: 10.1155/2018/8681792. eCollection 2018.

S-Amlodipine: An Isomer with Difference-Time to Shift from Racemic Amlodipine

Jamshed Dalal  1 , J C Mohan  2 , S S Iyengar  3 , Jagdish Hiremath  4 , Immaneni Sathyamurthy  5 , Sandeep Bansal  6 , Dhiman Kahali  7 , Arup Dasbiswas  8
Affiliations
Review

S-Amlodipine: An Isomer with Difference-Time to Shift from Racemic Amlodipine

Jamshed Dalal et al. Int J Hypertens. .

Abstract

Calcium channel blockers are among the first-line drugs for treatment of hypertension (HTN). S-amlodipine (S-AM), an S-enantiomer of amlodipine, is available in India and in other countries like China, Korea, Russia, Ukraine, and Nepal. Being clinically researched for nearly two decades, we performed in-depth review of S-AM. This review discusses clinical evidence from total 42 studies (26 randomized controlled trials, 14 observational studies, and 2 meta-analyses) corroborating over 7400 patients treated with S-AM. Efficacy and safety of S-AM in HTN in comparison to racemic amlodipine, used as monotherapy and in combination with other antihypertensives, efficacy in angina, and pleiotropic benefits with S-AM, are discussed in this review.

PubMed Disclaimer

References

    1. James P. A., Oparil S., Carter B. L., et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) Journal of the American Medical Association. 2014;311(5):507–520. doi: 10.1001/jama.2013.284427. - DOI - PubMed
    1. Rahimi K., Emdin C. A., MacMahon S. The Epidemiology of Blood Pressure and Its Worldwide Management. Circulation Research. 2015;116(6):925–935. doi: 10.1161/CIRCRESAHA.116.304723. - DOI - PubMed
    1. Dahlöf B., Sever P. S., Poulter N. R., et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. The Lancet. 2005;366(9489):895–906. doi: 10.1016/s0140-6736(05)67185-1. - DOI - PubMed
    1. Agrawal Y. K., Bhatt H. G., Raval H. G., Oza P. M., Gogoi P. J. Chirality - A new era of therapeutics. Mini-Reviews in Medicinal Chemistry. 2007;7(5):451–460. doi: 10.2174/138955707780619617. - DOI - PubMed
    1. Pathak L. Chiral switches in the management of hypertenison. BMJ (South Asia edition) 2005;21:668–669.

LinkOut - more resources