Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May 25:8:177.
doi: 10.3389/fcimb.2018.00177. eCollection 2018.

Herpesviruses: Harmonious Pathogens but Relevant Cofactors in Other Diseases?

Sharvan Sehrawat  1 , Dhaneshwar Kumar  1 , Barry T Rouse  2
Affiliations
Review

Herpesviruses: Harmonious Pathogens but Relevant Cofactors in Other Diseases?

Sharvan Sehrawat et al. Front Cell Infect Microbiol. .

Abstract

Most vertebrates are infected with one or more herpesviruses and remain so for the rest of their lives. The relationship of immunocompetent healthy host with herpesviruses may sometime be considered as harmonious. However, clinically severe diseases can occur when host immunity is compromised due to aging, during some stress response, co-infections or during neoplastic disease conditions. Discord can also occur during iatrogenic immunosuppression used for controlling graft rejection, in some primary genetic immunodeficiencies as well as when the virus infects a non-native host. In this review, we discuss such issues and their influence on host-herpesvirus interaction.

Keywords: cofactors; coinfections; disease outcome; herpesviruses; host–pathogen interactions; virome.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A cartoon to show the circumstances that are responsible for making and breaking herpesviruses and host harmony.
See this image and copyright information in PMC

References

    1. Abdollahpour H., Appaswamy G., Kotlarz D., Diestelhorst J., Beier R., Schaffer A. A., et al. . (2012). The phenotype of human STK4 deficiency. Blood 119, 3450–3457. 10.1182/blood-2011-09-378158 - DOI - PMC - PubMed
    1. Ahn K., Gruhler A., Galocha B., Jones T. R., Wiertz E. J. H., Ploegh H. L., et al. . (1997). The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity 6, 613–621. 10.1016/S1074-7613(00)80349-0 - DOI - PubMed
    1. Albrecht M. A., DeLuca N. A., Byrn R. A., Schaffer P. A., Hammer S. M. (1989). The herpes simplex virus immediate-early protein, ICP4, is required to potentiate replication of human immunodeficiency virus in CD4+ lymphocytes. J. Virol. 63, 1861–1868. - PMC - PubMed
    1. Angelini D. F., Serafini B., Piras E., Severa M., Coccia E. M., Rosicarelli B., et al. . (2013). Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis. PLoS Pathog. 9:e1003220. 10.1371/journal.ppat.1003220 - DOI - PMC - PubMed
    1. Antinone S. E., Smith G. A. (2010). Retrograde axon transport of herpes simplex virus and pseudorabies virus: a live-cell comparative analysis. J. Virol. 84, 1504–1512. 10.1128/JVI.02029-09 - DOI - PMC - PubMed

Publication types

MeSH terms