Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun 5;5(4):e469.
doi: 10.1212/NXI.0000000000000469. eCollection 2018 Jul.

Unusual neurologic presentation of aseptic abscesses syndrome

Philippe Nicolas  1 , Olivier Guerrier  1 , Amandine Benoit  1 , Francoise Durand-Dubief  1 , Gerald Raverot  1 , Sebastien Debarbieux  1 , Clemence Delteil  1 , Alexandre Vasiljevic  1 , Emmanuel Jouanneau  1 , Francois Cotton  1 , Romain Marignier  1 , Sandra Vukusic  1
Affiliations

Unusual neurologic presentation of aseptic abscesses syndrome

Philippe Nicolas et al. Neurol Neuroimmunol Neuroinflamm. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure. Skin, spleen, and hypothalamic-pituitary lesions
(A–D) Skin lesions: pyoderma gangrenosum (PG)-like ulceration of the elbow (A) and large pustules on the ankle surrounded by an inflammatory basis (B). Histopathologic aspect (courtesy of Dr. B. Balme Centre Hospitalier Lyon Sud) showing a dermal neutrophilic abscess (red circle). HES (hematoxylin, eosin, saffron) staining. Original magnification ×4 (C) and original magnification ×10 (D). (E and F) Spleen lesions: contrast-enhanced abdominal CT showing splenomegaly related to numerous splenic abscesses (red arrow) (E). Disappearance of the splenic abscesses after steroid treatment (F). (G–K) Hypothalamic-pituitary lesion. (G) Brain MRI: sequential contrast-enhanced sagittal T1-weighted images showing a voluminous (31 mm/17 mm/13 mm) gadolinium-enhancing hypothalamic-pituitary multiloculated lesion (red arrow). (H) Spontaneous vanishing of the hypothalamic-pituitary lesion. (I–K) Pituitary histopathology showing microabscesses (I; black arrow) composed of numerous neutrophils (J; arrowhead) and necrotic debris (K). Original magnification ×100 (I) and ×400 (J and K). Special histochemical stains (Gram, Grocott, PAS [Periodic acid-Schiff], and Ziehl) did not detect any bacteria, fungi, or mycobacteria. Universal and mycobacteria PCR were negative. Standard, parasite, and fungal cultures were sterile.
See this image and copyright information in PMC

References

    1. André MF, Piette JC, Kémény JL, et al. . Aseptic abscesses: a study of 30 patients with or without inflammatory bowel disease and review of the literature. Medicine (Baltimore) 2007;86:145–161. - PubMed
    1. Wallach D, Vignon-Pennamen MD. From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of clinical research. J Am Acad Dermatol 2006;55:1066–1071. - PubMed
    1. Bardy A, Guettrot-Imbert G, Aumaître O, André MF. Efficacy of Il-1β blockade in refractory aseptic abscesses syndrome. Mod Rheumatol 2014;24:217–219. - PubMed
    1. André MF, Aumaître O, Grateau G, et al. . Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients. Dig Dis Sci 2010;55:1681–1688. - PubMed
    1. Braswell SF, Kostopoulos TC, Ortega-Loayza AG. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015;73:691–698. - PubMed

LinkOut - more resources