Chemoenzymatic Deracemization of Chiral Sulfoxides
- PMID: 29888843
- DOI: 10.1002/anie.201805858
Chemoenzymatic Deracemization of Chiral Sulfoxides
Abstract
The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.
Keywords: biocatalysis; biphasic reactions; chiral sulfoxides; deracemization; oxidoreductases.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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