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. 2018 Jul 26;57(31):9849-9852.
doi: 10.1002/anie.201805858. Epub 2018 Jun 29.

Chemoenzymatic Deracemization of Chiral Sulfoxides

Vladimír Nosek  1 , Jiří Míšek  1
Affiliations

Chemoenzymatic Deracemization of Chiral Sulfoxides

Vladimír Nosek et al. Angew Chem Int Ed Engl. .

Abstract

The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.

Keywords: biocatalysis; biphasic reactions; chiral sulfoxides; deracemization; oxidoreductases.

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