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. 2018 Jun 7;27(2):84-87.
doi: 10.4274/mirt.59454.

I-131 Radiation-Induced Myelosuppression in Differentiated Thyroid Cancer Therapy

Stephan Probst  1 , Gad Abikhzer  1 , Guillaume Chaussé  1 , Michael Tamilia  2
Affiliations

I-131 Radiation-Induced Myelosuppression in Differentiated Thyroid Cancer Therapy

Stephan Probst et al. Mol Imaging Radionucl Ther. .

Abstract
in English, Turkish

Radioactive iodine (RAI) treatment of differentiated thyroid cancer has been used in clinical practice for almost 60 years and is generally accepted to be a safe and efficacious treatment. Severe toxicity in the form of radiation pneumonitis, sometimes progressing to fibrosis, and bone marrow suppression are reported but remain rare. We present a case of severe myelosuppression requiring hospitalization and transfusion support in an otherwise well, young female patient who had received 175 mCi I-131 for low-volume micronodular lung disease one month prior, with a cumulative lifetime administered activity of 575 mCi. The most important risk factors for myelosuppression following RAI are the activity received, the amount of functioning thyroid tissue present, and the lifetime cumulative activity received.

Radyoaktif iyot (RAİ) diferansiye tiroid kanseri tedavisinde yaklaşık 60 yıldır klinik uygulamada kullanılmaktadır ve genellikle güvenli ve etkili bir tedavi olarak kabul edilir. Fibrozise ilerleyebilen radyasyon pnömonisi ve kemik iliği süpresyonu gibi ciddi yan etkiler bildirilmiştir ancak nadiren rastlanır. Bu makalede bir ay önce düşük volümlü mikronodüler akciğer hastalığı için 175 mCi I-131 tedavisi, hayat boyu uygulanan kümülatif aktivite 575 mCi, aldıktan sonra ciddi miyelosüpresyon nedeniyle hastane yatışı ve transfüzyon desteği ihtiyacı olan genç bir kadın hasta sunulmaktadır. RAİ sonrası miyelosüpresyon için en önemli risk faktörleri alınan aktivite miktarı, mevcut fonksiyonel tiroid dokusu ve alınan hayat boyu kümülatif aktivite miktarıdır.

Keywords: Iodine radioisotopes; bone marrow thyroid neoplasms..

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Graphic 1
Graphic 1. Hematologic parameters WBC: White blood cells, Hg: Hemoglobin
See this image and copyright information in PMC

References

    1. Dorn R, Kopp J, Vogt H, Heidenreich P, Carroll RG, Gulec SA. Dosimetry-guided radioactive iodine treatment in patients with metastatic differentiated thyroid cancer: largest safe dose using a risk-adapted approach. J Nucl Med. 2003;44:451–456. - PubMed
    1. Menzel C, Grünwald F, Schomburg A, Palmedo H, Bender H, Späth G, Biersack HJ. “High-dose” radioiodine therapy in advanced differentiated thyroid carcinoma. J Nucl Med. 1996;37:1496–1503. - PubMed
    1. Rufini V, Salvatori M, Saletnich I, Luzi S, Fadda G, Shapiro B, Troncone L. Disseminated bone marrow metastases of insular thyroid carcinoma detected by radioiodine whole-body scintigraphy. J Nucl Med. 1996;37:633–636. - PubMed
    1. Freudenberg LS, Jentzen W, Görges R, Petrich T, Marlowe RJ, Knust J, Bockisch A. 124I-PET dosimetry in advanced differentiated thyroid cancer: therapeutic impact. Nuklearmedizin. 2007;46:121–128. - PubMed
    1. Keldsen N, Mortensen BT, Hansen HS. Haematological effects from radioiodine treatment of thyroid carcinoma. Acta Oncol. 1990;29:1035–1039. - PubMed

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