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. 2018 Jun 11;13(6):e0198800.
doi: 10.1371/journal.pone.0198800. eCollection 2018.

The clinical impact of supraclavicular lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

Yen-Hao Chen  1   2   3 , Hung-I Lu  4 , Chien-Ming Lo  4 , Yu-Ming Wang  5 , Shang-Yu Chou  5 , Cheng-Hua Huang  1 , Li-Hsueh Shih  6 , Su-Wei Chen  7 , Shau-Hsuan Li  1
Affiliations

The clinical impact of supraclavicular lymph node metastasis in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

Yen-Hao Chen et al. PLoS One. .

Abstract

Background: To evaluate the clinical significance of supraclavicular lymph node (SCLN) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

Materials and methods: We retrospectively analyzed all 369 locally advanced ESCC patients treated with CCRT between 2000 and 2015, including 70 patients with SCLN metastasis and 299 patients without SCLN metastasis.

Results: For these locally advanced ESCC patients treated with curative CCRT, N0-2 were significantly associated with superior progression-free survival (PFS) and overall survival (OS) in univariate and multivariable analyses. However, there were no significant differences in PFS and OS between the SCLN metastasis and non-SCLN metastasis groups; a subgroup analysis also revealed there was no significant differences in PFS and OS between patients with and without SCLN metastasis either in the N0-2 or in the N3 subgroup analysis.

Conclusions: Our study suggests that SCLN metastasis is not a prognostic factor in locally advanced ESCC patients receiving curative CCRT, and that SCLNs should be considered to be regional LNs and treated with curative intent.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The survival curves of 70 esophageal squamous cell carcinoma patients with supraclavicular lymph node (SCLN) metastasis compared to the 299 patients without SCLN metastasis.
(A) Progression-free survival. (B) Overall survival.
Fig 2
Fig 2. Comparison of survival curves of esophageal squamous cell carcinoma patients with or without SCLN metastasis in different N statuses.
(A) N0-2 status, progression-free survival (B) N0-2 status, overall survival. (C) N3 status, progression-free survival (D) N3 status, overall survival. SCLN: supraclavicular lymph node.
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinicians. 2015;65(2):87–108. doi: 10.3322/caac.21262 . - DOI - PubMed
    1. National Department of Health, Republic of China. Cancer Registry Annual Report 1972–2009.
    1. Burmeister BH, Smithers BM, Gebski V, Fitzgerald L, Simes RJ, Devitt P, et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. The Lancet Oncology. 2005;6(9):659–68. doi: 10.1016/S1470-2045(05)70288-6 . - DOI - PubMed
    1. Hsu PK, Wu YC, Chou TY, Huang CS, Hsu WH. Comparison of the 6th and 7th editions of the American Joint Committee on Cancer tumor-node-metastasis staging system in patients with resected esophageal carcinoma. The Annals of thoracic surgery. 2010;89(4):1024–31. doi: 10.1016/j.athoracsur.2010.01.017 . - DOI - PubMed
    1. Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, et al. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. The New England journal of medicine. 1998;339(27):1979–84. doi: 10.1056/NEJM199812313392704 . - DOI - PubMed

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