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Review
. 2018 Jun 10;19(6):1721.
doi: 10.3390/ijms19061721.

Potential Clinical Application of Genomics in Multiple Myeloma

Cinnie Yentia Soekojo  1 , Sanjay de Mel  2 , Melissa Ooi  3 , Benedict Yan  4 , Wee Joo Chng  5   6
Affiliations
Review

Potential Clinical Application of Genomics in Multiple Myeloma

Cinnie Yentia Soekojo et al. Int J Mol Sci. .

Abstract

Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma.

Keywords: gene expression profiling; genomics; multiple myeloma.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Landgren O., Morgan G.J. Biologic frontiers in multiple myeloma: From biomarker identification to clinical practice. Clin. Cancer Res. 2014;20:804–813. doi: 10.1158/1078-0432.CCR-13-2159. - DOI - PMC - PubMed
    1. Wan T.S. Cancer cytogenetics: Methodology revisited. Ann. Lab. Med. 2014;34:413–425. doi: 10.3343/alm.2014.34.6.413. - DOI - PMC - PubMed
    1. Howe B., Umrigar A., Tsien F. Chromosome preparation from cultured cells. JoVE J. 2014:e50203. doi: 10.3791/50203. - DOI - PMC - PubMed
    1. Fonseca R., Debes-Marun C.S., Picken E.B., Dewald G.W., Bryant S.C., Winkler J.M., Blood E., Oken M.M., Santana-Davila R., Gonzalez-Paz N., et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood. 2003;102:2562–2567. doi: 10.1182/blood-2003-02-0493. - DOI - PubMed
    1. Smadja N.V., Fruchart C., Isnard F., Louvet C., Dutel J.L., Cheron N., Grange M.J., Monconduit M., Bastard C. Chromosomal analysis in multiple myeloma: Cytogenetic evidence of two different diseases. Leukemia. 1998;12:960–969. doi: 10.1038/sj.leu.2401041. - DOI - PubMed

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