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Comment
. 2018 Jun 26;115(26):6528-6529.
doi: 10.1073/pnas.1808196115. Epub 2018 Jun 11.

HoxB13 mediates AR-V7 activity in prostate cancer

Héctor I Navarro  1 , Andrew S Goldstein  2   3   4   5
Affiliations
Comment

HoxB13 mediates AR-V7 activity in prostate cancer

Héctor I Navarro et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Model of HoxB13-mediated AR-V7 oncogenic function. (A) AR-V7 genomic binding is dependent on HoxB13, and genes up-regulated by AR-V7 are heterogeneous between distinct CRPC patients, ultimately leading to tumor cell proliferation. (B) HoxB13 targeting is sufficient to inhibit CRPC tumor growth.
See this image and copyright information in PMC

Comment on

  • Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.
    Chen Z, Wu D, Thomas-Ahner JM, Lu C, Zhao P, Zhang Q, Geraghty C, Yan PS, Hankey W, Sunkel B, Cheng X, Antonarakis ES, Wang QE, Liu Z, Huang TH, Jin VX, Clinton SK, Luo J, Huang J, Wang Q. Chen Z, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6810-6815. doi: 10.1073/pnas.1718811115. Epub 2018 May 29. Proc Natl Acad Sci U S A. 2018. PMID: 29844167 Free PMC article.

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    1. Chen Z, et al. Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proc Natl Acad Sci USA. 2018;115:6810–6815. - PMC - PubMed

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