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. 2018 May;62(3):247-253.
doi: 10.3164/jcbn.17-101. Epub 2018 Mar 30.

Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-aged and older women

Keisei Kosaki  1 , Atsuko Kamijo-Ikemori  2   3 , Takeshi Sugaya  2   4 , Koichiro Tanahashi  1 , Nobuhiko Akazawa  5   6 , Chihiro Hibi  7 , Takashi Nakamura  7 , Takayo Murase  8 , Kenjiro Kimura  9 , Yugo Shibagaki  2 , Seiji Maeda  5
Affiliations

Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-aged and older women

Keisei Kosaki et al. J Clin Biochem Nutr. 2018 May.

Abstract

The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women. In the interventional study, subjects (n = 22) were divided into two groups: exercise (n = 12) or the control group (n = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreductase activity in middle-aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity was significantly associated with various physiological parameters, including visceral fat and daily step counts. In the interventional study, the plasma xanthine oxidoreductase activity significantly decreased after the 12-week aerobic exercise training, its changes were inversely associated with the changes in daily step counts. Our results revealed that the plasma xanthine oxidoreductase activity was associated with visceral fat accumulation and lack of exercise, and it was decreased by the aerobic exercise training.

Keywords: aerobic exercise training; cardiovascular disease risks; daily step counts; visceral fat.

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Figures

Fig. 1
Fig. 1
Univariate correlations between log-transformed XOR activity and various physiological parameters. XOR, xanthine oxidoreductase.
Fig. 2
Fig. 2
Changes in daily step counts (A), visceral fat (B), plasma XOR activity (C) and carotid AIx (D), after the 12-week aerobic exercise training. Data are presented as the mean ± SE of the mean. XOR, xanthine oxidoreductase; AIx, augmentation index.
Fig. 3
Fig. 3
Associations between the changes in daily step counts and visceral fat (A), plasma XOR activity (B) and carotid AIx (C), after the 12-week aerobic exercise training. XOR, xanthine oxidoreductase; AIx, augmentation index.
See this image and copyright information in PMC

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