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Case Reports
. 2018 Apr 9:9:45-47.
doi: 10.1016/j.lrr.2018.04.001. eCollection 2018.

A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia

Mattias Hofmans  1 , Anke Delie  2 , Karl Vandepoele  3   4   5 , Nadine Van Roy  6   4 , Joni Van der Meulen  6   4   5 , Jan Philippé  1   4 , Ine Moors  2
Affiliations
Case Reports

A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia

Mattias Hofmans et al. Leuk Res Rep. .

Abstract

The natural history of primary eosinophilia remains highly variable and is characterized by underlying disease heterogeneity. Chronic eosinophilic leukemia, not otherwise specified (CEL-NOS) is a rare and aggressive disease characterized by non-specific cytogenetic abnormalities or elevated blasts, with high risk of transformation to acute leukemia. We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS.

Keywords: CEL-NOS; Decitabine; Hypereosinophilia; NPM1 mutation; Secondary AML.

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Figures

Fig. 1
Fig. 1
(a) Peripheral blood smear showing eosinophilia with eosinophilic precursors, aberrant granulation, and vacuolisation (May-Grunwald-Giemsa staining, 500×). (b) Bone marrow aspirate showing hypercellular marrow with striking presence of eosinophils and eosinophil precursors with dysplastic features, abnormal nuclei and aberrant mixed granulation (May-Grunwald-Giemsa staining, 500×). (c and d) Bone marrow aspirate five months after the initial diagnosis of CEL showing increased number of myeloblasts with presence of Auer rods and mild dysplasia in the erythroid lineage (May-Grunwald-Giemsa staining, 500×).
See this image and copyright information in PMC

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