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Case Reports
. 2019 Jan 1;68(1):139-142.
doi: 10.1093/cid/ciy486.

Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Arthur W D Edridge  1   2 , Martin Deijs  1 , Ruth Namazzi  3 , Cosimo Cristella  1 , Maarten F Jebbink  1 , Irma Maurer  4 , Neeltje A Kootstra  4 , Linda R Buluma  3 , Job B M van Woensel  2 , Menno D de Jong  1 , Richard Idro  3 , Michael Boele van Hensbroek  2 , Lia van der Hoek  1
Affiliations
Case Reports

Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy

Arthur W D Edridge et al. Clin Infect Dis. .

Abstract

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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Figures

Figure 1.
Figure 1.
A, Map of central and western Uganda. The hometown of the patient, Ntwetwe village, is marked in blue; the hospitals visited by the patient are marked in red. Recent reports of bunyavirus outbreaks reported to ProMED-Mail since November 2017 are marked in purple and orange. Central forest reserves are in green, wildlife reserves are in yellow, and national parks are in brown. B, Phylogenetic analysis on amino acid sequences of the N protein (coded by the S-segment), glycoprotein precursor polyprotein (coded by the M-segment), and L protein (coded by the L-segment). The Ntwetwe virus amino acid sequence was based on translated nucleotide sequences of 283, 178, and 936 nucleotides of the S, M, and L segments, respectively. Known serogroups are coded by color. GenBank accession numbers (MH324826, MH324827, MH324828) are provided for each viral segment. Abbreviation: DRC, Democratic Republic of Congo.
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