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Case Reports
. 1985 Jun;48(6):576-8.
doi: 10.1136/jnnp.48.6.576.

Peripheral neuropathy during longterm high-dose amiodarone therapy

A G Fraser, I N McQueen, A H Watt, M R Stephens
Case Reports

Peripheral neuropathy during longterm high-dose amiodarone therapy

A G Fraser et al. J Neurol Neurosurg Psychiatry. 1985 Jun.

Abstract

Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.

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