The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others

Abstract

Epithelial ovarian cancer (EOC) accounts for 90% of all ovarian cancer. Initially, approaching 80% of EOC patients respond to standard therapeutic strategy, cytoreduction combining with postoperative auxiliary platinum-based chemotherapy. However, relapse is approximately inevitable because of drug-resistance for high-grade serous ovarian cancer (HGSOC). Recently, the nuclear enzyme poly (ADP-ribose) polymerase (PARP) represents a strikingly novel target in EOC treatment. PARP inhibitors, currently mainly including Olaparib, Niraparib, Velaparib, Rucaparib, and Talazoparib, have demonstrated promising activity in EOC treatment. Especially, studies of Olaparib accelerated it to be approved in Europe and USA. Here, this review focuses on the pre-clinical data, current clinical trials, the development of PARP inhibitors in the last decade and their future roles in clinical treatment for EOC patients.

Keywords: Epithelial ovarian cancer; Niraparib; Olaparib; PARP inhibitor; Rucaparib; Veliparib.