[The research progress of relationship between advanced glycation end products and diabetic keratopathy]
- PMID: 29895121
- DOI: 10.3760/cma.j.issn.0412-4081.2018.06.018
[The research progress of relationship between advanced glycation end products and diabetic keratopathy]
Abstract
Diabetic keratopathy is a common ocular complication of patients with a long-term history of diabetes and it will have a negative effect on the visual quality and function. A study reported that the incidence of diabetic keratopathy in diabetic patients ranged from 47% to 64%, but the precise underlying pathogenesis remains unclear. There is evidence that advanced glycation end products contribute substantially to the onset and progress of various diabetic complications and it is a key factor for the mechanism of the hyperglycemic memory. This review focuses primarily on the present research state and prospect of advanced glycation end products and their role in the pathological changes of the cornea. (Chin J Ophthalmol, 2018, 54: 475-480).
糖尿病角膜病变是常见的糖尿病眼部并发症之一，47%~64%患者在糖尿病病程中会出现该眼部疾患，严重影响患者的视觉质量和视功能。目前发病机制尚不完全明确。大量研究结果证实晚期糖基化终末产物（AGEs）是引起糖尿病慢性并发症的重要因素之一，同时AGEs参与糖尿病高血糖记忆效应的发生。本文就AGEs与糖尿病角膜病变的研究现状及研究前景进行总结和分析，以期为临床进行相关研究提供参考。（中华眼科杂志，2018，54：475-480）.
Keywords: Advanced glycosylation end product-specific receptor; Corneal diseases; Diabetes complications; Glycosylation end products, advanced.