Comment
doi: 10.1016/j.tibs.2018.05.001.
Epub 2018 Jun 9.
Unraveling Endocrine FGF Signaling Complex to Combat Metabolic Diseases
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- PMID: 29895507
- DOI: 10.1016/j.tibs.2018.05.001
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Comment
Unraveling Endocrine FGF Signaling Complex to Combat Metabolic Diseases
Trends Biochem Sci.
2018 Aug.
Abstract
Metabolic homeostasis is critical to cellular and organismal health. The newly revealed crystal structures of the endocrine factors FGF21 and FGF23, in association with the glycosidase coreceptor Klotho and transmembrane tyrosine kinase FGFR, set a platform for structure-based novel drug design against common metabolic disorders.
Keywords: FGF21; FGF23; FGFR; Klotho; heparan sulfate; metabolic diseases.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Comment on
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Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.Nature. 2018 Jan 25;553(7689):501-505. doi: 10.1038/nature25010. Epub 2018 Jan 17. Nature. 2018. PMID: 29342135 Free PMC article.
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α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.Nature. 2018 Jan 25;553(7689):461-466. doi: 10.1038/nature25451. Epub 2018 Jan 17. Nature. 2018. PMID: 29342138 Free PMC article.
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