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. 2018 Jul;16(1):161-166.
doi: 10.3892/etm.2018.6159. Epub 2018 May 11.

Curative effect of posterior lumbar interbody fusion in the treatment of single-segment lumbar degenerative disease and changes in adjacent segment quantitative score

Yan Zhuang  1 , Feng Zhou  1 , Yunqin Zhang  1 , Zheng Jin  1
Affiliations

Curative effect of posterior lumbar interbody fusion in the treatment of single-segment lumbar degenerative disease and changes in adjacent segment quantitative score

Yan Zhuang et al. Exp Ther Med. 2018 Jul.

Abstract

Curative effect of posterior lumbar interbody fusion (PLIF) in the treatment of single-segment lumbar degenerative disease and changes in adjacent segment quantitative score was investigated. A total of 86 patients with single-segment lumbar degenerative disease were randomly selected and divided into control group (n=43) and observation group (n=43). The control group was treated with posterolateral lumbar fusion, while the observation group was treated with PLIF. The observation group had a significantly longer operation time and shorter hospitalization time compared with the control group (P<0.05). The excellent-good rate of treatment in the observation group (90.69%) was obviously higher than that in the control group (62.79%) (P<0.05). The levels of creatine phosphokinase in the two groups were significantly increased at 1, 3 and 5 days after operation (P<0.05), and reached the peak at 1 day after operation and returned to normal basically at 7 days after operation. Oswestry disability index in the observation group at 1, 6 and 12 months after operation were significantly lower than those in the control group (P<0.05). There was no significant difference in the MRI-T2 relaxation time of multifidus muscle at 3 months after operation between the two groups (P>0.05). The grade I and II interbody fusion rates in the observation group at 12 months after operation were significantly higher than those in the control group (P<0.05). The mean spinal canal areas and adjacent segment quantitative scores in the two groups after operation were significantly improved compared with those before operation, and they were improved more obviously in the observation group than those in the control group (P<0.05). PLIF has a more definite short-term curative effect and a higher interbody fusion rate in the treatment of single-segment lumbar degenerative disease, which is more conducive to promoting the postoperative rehabilitation of patients and slowing down the occurrence of adjacent segment degeneration.

Keywords: adjacent segment quantitative score; posterior lumbar interbody fusion; single-segment lumbar degenerative disease.

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Figures

Figure 1.
Figure 1.
CPK levels in the two groups before and after operation. CPK, creatine phosphokinase.*P<0.05, compared with the observation group before surgery; #P<0.05, compared with the control group before surgery.
Figure 2.
Figure 2.
MRI-T2 relaxation time at 3 months after surgery between the two groups. MRI, magnetic resonance imaging.
Figure 3.
Figure 3.
Spinal canal areas before and after operation between the two groups. *P<0.05, compared with the control group.
See this image and copyright information in PMC

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References

    1. Kreiner DS, Shaffer WO, Baisden JL, Gilbert TJ, Summers JT, Toton JF, Hwang SW, Mendel RC, Reitman CA. North American Spine Society: An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis (update) Spine J. 2013;13:734–743. doi: 10.1016/j.spinee.2012.11.059. - DOI - PubMed
    1. Manchikanti L, Benyamin RM, Falco FJ, Kaye AD, Hirsch JA. Do epidural injections provide short- and long-term relief for lumbar disc herniation? A systematic review. Clin Orthop Relat Res. 2015;473:1940–1956. doi: 10.1007/s11999-014-3490-4. - DOI - PMC - PubMed
    1. Shamji MF, Mroz T, Hsu W, Chutkan N. Management of degenerative lumbar spinal stenosis in the elderly. Neurosurgery. 2015;77(Suppl 4):S68–S74. doi: 10.1227/NEU.0000000000000943. - DOI - PubMed
    1. Shin JS, Oh SH, Cho PG. Surgical outcome of a zero-profile device comparing with stand-alone cage and anterior cervical plate with iliac bone graft in the anterior cervical discectomy and fusion. Korean J Spine. 2014;11:169–177. doi: 10.14245/kjs.2014.11.3.169. - DOI - PMC - PubMed
    1. Hikata T, Kamata M, Furukawa M. Risk factors for adjacent segment disease after posterior lumbar interbody fusion and efficacy of simultaneous decompression surgery for symptomatic adjacent segment disease. J Spinal Disord Tech. 2014;27:70–75. doi: 10.1097/BSD.0b013e31824e5292. - DOI - PubMed