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. 2018 Jul;16(1):328-332.
doi: 10.3892/etm.2018.6169. Epub 2018 May 16.

Differential network as an indicator of osteoporosis with network entropy

Lili Ma  1 , Hongmei Du  1 , Guangdong Chen  1
Affiliations

Differential network as an indicator of osteoporosis with network entropy

Lili Ma et al. Exp Ther Med. 2018 Jul.

Abstract

Osteoporosis is a common skeletal disorder characterized by a decrease in bone mass and density. The peak bone mass (PBM) is a significant determinant of osteoporosis. To gain insights into the indicating effect of PBM to osteoporosis, this study focused on characterizing the PBM networks and identifying key genes. One biological data set with 12 monocyte low PBM samples and 11 high PBM samples was derived to construct protein-protein interaction networks (PPINs). Based on clique-merging, module-identification algorithm was used to identify modules from PPINs. The systematic calculation and comparison were performed to test whether the network entropy can discriminate the low PBM network from high PBM network. We constructed 32 destination networks with 66 modules divided from monocyte low and high PBM networks. Among them, network 11 was the only significantly differential one (P<0.05) with 8 nodes and 28 edges. All genes belonged to precursors of osteoclasts, which were related to calcium transport as well as blood monocytes. In conclusion, based on the entropy in PBM PPINs, the differential network appears to be a novel therapeutic indicator for osteoporosis during the bone monocyte progression; these findings are helpful in disclosing the pathogenetic mechanisms of osteoporosis.

Keywords: network entropy; osteoporosis; peak bone mass; protein-protein interaction networks.

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Figures

Figure 1.
Figure 1.
The significantly differential network divided from PBM PPI. The differential PBM network with 8 nodes and 28 edges, a total of 8 genes, PSMA2, PSMB1, PSMC1, PSMC4, PSMD5, PSMD7, PSMD8 and PSMD11, were identified in both monocyte low and high PBM networks. They belonged to precursors of macropain, which were related to calcium transport as well as blood monocytes. PBM, peak bone mass; PPI, protein-protein interaction.
Figure 2.
Figure 2.
Bone density of right femur and third lumbar vertebra (*P<0.05).
Figure 3.
Figure 3.
The expression of target genes in network. OVX and SHAM represent ovariectomized and sham operated group, respectively (*P<0.05).
See this image and copyright information in PMC

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