Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Jan 12;4(2):162-168.
doi: 10.1016/j.artd.2017.12.004. eCollection 2018 Jun.

Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty

Alexander Arzeno  1 , Tim Wang  1 , James I Huddleston 3rd  1
Affiliations
Case Reports

Abundant heterotopic bone formation following use of rhBMP-2 in the treatment of acetabular bone defects during revision hip arthroplasty

Alexander Arzeno et al. Arthroplast Today. .

Abstract

Revision hip arthroplasty in the setting of periacetabular bone loss presents a significant challenge, as options for restoring bone loss are limited. Recombinant human bone morphogenetic protein-2 may offer a solution by promoting bone growth to restore bone stock before implant reimplantation. Here we present a case of a patient with a periprosthetic acetabulum fracture, resulting in pelvic discontinuity as the result of significant periacetabular bone loss. Using a staged approach, periacetabular bone stock was nearly entirely reconstituted using recombinant BMPs and allograft, which resulted in stable fixation, but with abundant heterotopic bone formation. Recombinant BMP-2 offers a useful tool for restoring bone stock in complex hip arthroplasty revision cases with periacetabular bone loss; however, caution must be used as overabundant bone growth as heterotopic ossification may result.

Keywords: Bone defects; Revision arthroplasty; rhBMP-2.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Preoperative pelvic radiographs. Anteroposterior (AP) (a), inlet (b), outlet (c), obturator oblique (d), and iliac oblique (e) images.
Figure 2
Figure 2
Postoperative radiograph taken immediately after the first staged surgery.
Figure 3
Figure 3
Two months after explant and bone grafting postoperative radiographs of the pelvis (a), hip AP (b), and lateral (c).
Figure 4
Figure 4
Radiographs taken after the second stage of the procedure. Immediately postoperative (a), 8 months postoperative AP pelvis (b), AP hip (c), and lateral hip (d).
Figure 5
Figure 5
BMP gene transcription pathway.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Urist M.R. Bone: formation by autoinduction. Science. 1965;150(3698):893. - PubMed
    1. Ebara S., Nakayama K. Mechanism for the action of bone morphogenetic proteins and regulation of their activity. Spine (Phila Pa 1976) 2002;27(16 Suppl 1):S10. - PubMed
    1. ten Dijke P., Fu J., Schaap P., Roelen B.A. Signal transduction of bone morphogenetic proteins in osteoblast differentiation. J Bone Joint Surg Am. 2003;85-A Suppl 3:34. - PubMed
    1. Sampath T.K., Reddi A.H. Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix. Proc Natl Acad Sci U S A. 1983;80(21):6591. - PMC - PubMed
    1. Wozney J.M., Rosen V., Celeste A.J. Novel regulators of bone formation: molecular clones and activities. Science. 1988;242(4885):1528. - PubMed

Publication types

LinkOut - more resources