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. 1985 Jun;315(6021):641-7.
doi: 10.1038/315641a0.

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

C J March, B Mosley, A Larsen, D P Cerretti, G Braedt, V Price, S Gillis, C S Henney, S R Kronheim, K Grabstein, et al.

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

C J March et al. Nature. 1985 Jun.

Abstract

Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.

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