Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul 1;33(4):261-268.
doi: 10.1152/physiol.00016.2018.

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension

Baptiste Rode  1   2 , Marc A Bailey  2 , Roger Marthan  1   3   4 , David J Beech  2 , Christelle Guibert  1   3
Affiliations
Review

ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension

Baptiste Rode et al. Physiology (Bethesda). .

Abstract

Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2+ channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources