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Review
. 2018 Jun 13:361:k2139.
doi: 10.1136/bmj.k2139.

Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance

Affiliations
Review

Dietary fat and cardiometabolic health: evidence, controversies, and consensus for guidance

Nita G Forouhi et al. BMJ. .

Abstract

Although difficulties in nutrition research and formulating guidelines fuel ongoing debate, the complexities of dietary fats and overall diet are becoming better understood, argue Nita G Forouhi and colleagues

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Conflict of interest statement

Competing interests: We have read and understood BMJ policy on declaration of interests and declare the following: NGF receives funding from the Medical Research Council Epidemiology Unit (MC_UU_12015/5). She is a member (unpaid) of the Joint SACN/NHS-England/Diabetes-UK Working Group to review the evidence on lower carbohydrate diets compared with current government advice for adults with type 2 diabetes and is a member (unpaid) of ILSI-Europe Qualitative Fat Intake Task Force Expert Group on update on health effects of different saturated fats. RK has held grants from the National Institutes of Health, Dairy Management, Inc., Almond Board of California, and Quest Diagnostics. He also licensed a patent for ion mobility analysis of lipoprotein particles. He is on the scientific advisory board of Virta Health and has received honoraria from Quest Diagnostics and Crossfit Foundation. GT is a director at Nutrition Science Initiative, senior editor at Crossfit Health, and author of several books and blogs on diet and health. WCW has no competing interests to declare.

Figures

Fig 1
Fig 1
Diet-heart hypothesis and current understanding. HDL: high density lipoprotein, HDLc: high density lipoprotein cholesterol, LDL: low density lipoprotein

References

    1. Sacks FM, Lichtenstein AH, Wu JHY, et al. American Heart Association dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation 2017;136:e1-23. 10.1161/CIR.0000000000000510 - DOI - PubMed
    1. Dehghan M, Mente A, Zhang X, et al. Prospective Urban Rural Epidemiology (PURE) study investigators Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study. Lancet 2017;390:2050-62. 10.1016/S0140-6736(17)32252-3 - DOI - PubMed
    1. Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 2017;38:2459-72. 10.1093/eurheartj/ehx144 - DOI - PMC - PubMed
    1. Micha R, Mozaffarian D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence. Lipids 2010;45:893-905. 10.1007/s11745-010-3393-4 - DOI - PMC - PubMed
    1. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146-55. 10.1093/ajcn/77.5.1146 - DOI - PubMed