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. 2018 Mar 28:18:1134-1141.
doi: 10.1016/j.dib.2018.03.103. eCollection 2018 Jun.

Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

Harshal S Patil  1 , Dipesh D Jadhav  1 , Ajay Paul  1 , Fayaj A Mulani  1   2 , Shrikant J Karegaonkar  1   2 , Hirekodathakallu V Thulasiram  1   2   3
Affiliations

Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

Harshal S Patil et al. Data Brief. .

Abstract

In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.

Keywords: Andrographolide; Antimicrobial; Lipase.

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Figures

Fig. 1
Fig. 1
HPLC chromatogram of (A) Reaction mixture Amano lipase AK [0.1 mmol Andrographolide 1.0 mmol vinyl acetate, 5 mg of Amano lipase AK; 55 °C / 1 h; Acetone, 100 rpm, (B) Andrographolide (C) Andrographolide-14-acetate, (D) Co-injection of Andrographolide-14-acetate.
Fig. 2
Fig. 2
High-resolution mass spectra of andrographolide-14-acetate (2).
See this image and copyright information in PMC

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