Review
doi: 10.1126/science.2990035.
The granulocyte-macrophage colony-stimulating factors
- PMID: 2990035
- DOI: 10.1126/science.2990035
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Review
The granulocyte-macrophage colony-stimulating factors
Science.
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Abstract
The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.
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