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. 1985 Jul 5;229(4708):60-2.
doi: 10.1126/science.2990038.

Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle

T Nelson, G Lucignani, S Atlas, A M Crane, G A Dienel, L Sokoloff

Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle

T Nelson et al. Science. .

Abstract

Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.

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