Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr 5;3(2):81-82.
doi: 10.1016/j.synbio.2018.03.002. eCollection 2018 Jun.

RiPPing apart the rules for peptide natural products

Affiliations

RiPPing apart the rules for peptide natural products

Aman S Imani et al. Synth Syst Biotechnol. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Synth Syst Biotechnol. 2020 Oct 14;5(4):330-331. doi: 10.1016/j.synbio.2020.10.001. eCollection 2020 Dec. Synth Syst Biotechnol. 2020. PMID: 33102827 Free PMC article.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Enzymatic transformations recently discovered in RiPP biosynthesis providing peptide scaffolds once thought exclusive to NRPS pathways.

References

    1. Walsh C.T., O’Brien R.V., Khosla C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angew Chem. 2013;52(28):7098–7124. https://doi.org/10.1002/anie.201208344 (International Ed. in English) - DOI - PMC - PubMed
    1. Arnison P.G., Bibb M.J., Bierbaum G., Bowers A.A., Bugni T.S., Bulaj G., …, van der Donk W.A. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013;30(1):108–160. https://doi.org/10.1039/c2np20085f - DOI - PMC - PubMed
    1. Morinaka B.I., Lakis E., Verest M., Helf M.J., Scalvenzi T., Vagstad A.L., …, Piel J. Natural noncanonical protein splicing yields products with diverse β-amino acid residues. Science. 2018;359(6377):779–782. https://doi.org/10.1126/science.aao0157 - DOI - PubMed
    1. Freeman M.F., Gurgui C., Helf M.J., Morinaka B.I., Uria A.R., Oldham N.J., …, Piel J. Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. Science (New York, N.Y.) 2012;338(6105):387–390. https://doi.org/10.1126/science.1226121 - DOI - PubMed
    1. Morinaka B.I., Vagstad A.L., Helf M.J., Gugger M., Kegler C., Freeman M.F., …, Piel J. Radical S-adenosyl methionine epimerases: regioselective introduction of diverse D-amino acid patterns into peptide natural products. Angew Chem. 2014;53(32):8503–8507. https://doi.org/10.1002/anie.201400478 (International Ed. in English) - DOI - PubMed

LinkOut - more resources